Power unit boiler-turbine coordination system has some characteristics, such as delay, coupling, time-varying and model uncertainty. This paper designs a model predictive control strategy for the coordination process. It uses predictive model and the receding horizon optimal principle to reduce the effects of model uncertainty, time-varying and delay. Finally 300 MW power unit coordinated control system simulation experiment results show that the control system has fast load adaptability, disturbance rejection capability and robustness with the power unit condition changing and disturbance. The designed algorithm is a practical power unit coordination control method.