The micro-grid is an effective way to solve the uncontrolled and stochastic volatility of distributed generation connected to the grid, this paper analyzes the impact of distribution relay protection from micro-grid access. We put forward the requirements for primary equipment of distribution network, distribution network protection solution based on regional differential protection, and low-voltage distribution protection solution based on the positive and negative direction impedance. Actual project proved that regional differential protection better solves the impact of conventional distribution network multi sources protection and reclosure protection from micro-grid access, and positive and negative direction impedance relay solves the impact of low-voltage distribution network protection from distribution generation access.